Sure, I'd actually do things a bit different though. I'd use the first line in your advanced config search as the config block start. No need to repeat it in both places, might make your rule run quicker/better...
Then its just a matter of in the "Remediation" section to click on "Run script on each config block in violation". When you do this, it will preload the "Remediation script:" with
${ConfigBlockStartLine}
This will be replace with the first line of whatever matched your config block. In this case it should be the "interface XXX", then just add a line after it that will clear the description, I think that would just be:
no desc
Be sure to "Preview" the output to make sure it looks good, you might have to do some adjustments based on what you see here. But play with it a bit before you commit to doing it.